Does CBD interact with other medications?

Yes.  CBD is known to inhibit an enzyme called cytochrome P450.  It is the same effect that eating grapefruit can have on medications, and is involved in the metabolization of a number of drugs.

The inhibition of cytochrome P450 can have the effect of either increasing or decreasing the drug’s intended effect.  It is therefore advisable to ask your physician if any of your medications are in this category.

For more information, you can refer to CBD-Drug Interactions: The Role of Cytochrome P450.

2 Comments

  1. Gillian on March 5, 2018 at 9:58 am

    Hi my dog is on 0.5mg cyclavence every morning, 100mg gabapenton in the morning and at night, 2.5mg presidone (steroid) and 0.5mg amatriptyline at night.
    Can I give him CBD oil.

    Thank you

    • Ted Mortenson on March 5, 2018 at 3:15 pm

      Hi Gillian, as you probably know, both amatriptyline and gabapenton are medications for peripheral nerve pain. Both are toxic and dangerous, so if it were my dog, I would be giving it a high quality CBD product ( 3 times per day) such as are recommended in my Pet Product Reviews categories. The steroid is probably to reduce scratching and itchy skin… so basically, CBD does all these things without toxicity and side effects from prescription medications which are in my opinion not healthy at all. Steroid medication won’t work forever. Please consider reading the side effects of these medications. They are likely making things worse for your pet. However, CBD will not interact with these dangerous medications. CBD is completely non-toxic. CBD will replace all these drugs over time. That’s why I use it, pets benefit from it and millions of people throughout the ages. Soon you should be able to significantly reduce these prescription meds and your Pet will have a new lease on it’s current life experience.

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